Unlocking the Regulatory Genome by ARGUS: An Evidence-Constrained Agentic Framework for Interpreting Single Nucleotide Variants

arXiv:2610.12281 · q-bio.GN, cs.AI, cs.LG · Submitted 2026-10-08 · Read on arXiv

q-bio.GN, cs.AI, cs.LG

Submitted: 2026-10-08

Updated: 2026-10-08

Code: https://github.com/duttaprat/ARGUS

Terminology

Verifier — 18× in this paper · explained in 2 episodes
Agentic AI — 4× in this paper · explained in 1 episode
Hallucination — 4× in this paper · explained in 3 episodes
Agentic Framework — 2× in this paper · explained in 6 episodes
Agentic Reasoning — 2× in this paper · explained in 1 episode
Agentic Science — 2× in this paper · explained in 1 episode
Benchmark — 2× in this paper · explained in 2 episodes
Benchmarking — 2× in this paper · explained in 3 episodes
Core — 2× in this paper · explained in 2 episodes
Accuracy — 1× in this paper · explained in 1 episode
Adaptive Planning — 1× in this paper · explained in 1 episode
Agentic AI systems — 1× in this paper · explained in 1 episode
Agentic Loop — 1× in this paper · explained in 1 episode
Agentic System — 1× in this paper · explained in 2 episodes
Aggregation — 1× in this paper · explained in 1 episode
AlphaGenome Variant Impact — 1× in this paper
Failure Modes — 1× in this paper · explained in 3 episodes
Information Gain — 1× in this paper · explained in 2 episodes
Model-Agnostic — 1× in this paper · explained in 2 episodes
Provenance — 1× in this paper · explained in 3 episodes
Verification — 1× in this paper · explained in 2 episodes

Sources

DeepVRegulome: DNABERT-based deep-learning framework for predicting the functional impact of short genomic variants on the human regulome

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