ORBIT-FMIB: Tracking Order-Resolved Epistatic Information Through ESM-2

arXiv:2610.00672 · cs.LG, q-bio.QM · Submitted 2026-09-30 · Read on arXiv

cs.LG, q-bio.QM

Submitted: 2026-09-30

Updated: 2026-09-30

Terminology

• Aggregation — 9× in this paper · explained in 1 episode
• Transformer — 9× in this paper · explained in 2 episodes
• Foundation Model — 8× in this paper · explained in 3 episodes
• Benchmark — 7× in this paper · explained in 2 episodes
• Generalization — 7× in this paper · explained in 13 episodes
• Calibration — 6× in this paper · explained in 7 episodes
• Foundation Models — 6× in this paper · explained in 7 episodes
• Alignment — 5× in this paper · explained in 1 episode
• Trace — 5× in this paper · explained in 2 episodes
• Uncertainty Quantification — 3× in this paper · explained in 8 episodes
• Robustness — 2× in this paper · explained in 5 episodes
• Adaptation — 1× in this paper · explained in 1 episode
• Benchmarking — 1× in this paper · explained in 3 episodes
• Distribution Shift — 1× in this paper · explained in 5 episodes
• Frozen model — 1× in this paper · explained in 3 episodes
• Generative AI — 1× in this paper · explained in 2 episodes
• Generative Model — 1× in this paper · explained in 2 episodes
• Generative Models — 1× in this paper · explained in 2 episodes
• Grounding — 1× in this paper · explained in 3 episodes
• Mutual Information Neural Estimation — 1× in this paper
• Provenance — 1× in this paper · explained in 3 episodes

Sources

• BRIDGE: Bottleneck-Aware Regulator-Set Inference and Diagnosis for Cooperative Gene Regulatory Recovery
• Beyond Tokens: Probing Higher-Order Epistasis in Learned Protein Representations
• The information bottleneck method
• On Recovering Higher-order Interactions from Protein Language Models

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