Covariance Eigenspace Provides Latent Attribution of Longitudinal Effects in Brain Age Gap

arXiv:2609.40202 · q-bio.QM, eess.SP · Submitted 2026-09-30 · Read on arXiv

q-bio.QM, eess.SP

Submitted: 2026-09-30

Updated: 2026-09-30

Project page: https://atri-biostats.github.io/ADNIMERGE2

Terminology

• Mild Cognitive Impairment — 4× in this paper
• Integrated Gradients — 3× in this paper
• Interpretability — 3× in this paper · explained in 15 episodes
• Accuracy — 2× in this paper · explained in 1 episode
• Adam — 2× in this paper · explained in 2 episodes
• Latent Representation — 2× in this paper · explained in 2 episodes
• Latent Representations — 1× in this paper · explained in 3 episodes
• Latent Space — 1× in this paper · explained in 7 episodes
• Longitudinal Data — 1× in this paper · explained in 2 episodes
• Reconstruction Error — 1× in this paper · explained in 2 episodes
• Representation Learning — 1× in this paper · explained in 2 episodes
• Shapley values — 1× in this paper · explained in 2 episodes
• Trace — 1× in this paper · explained in 2 episodes

Sources

• Generalized SHAP: Generating multiple types of explanations in machine learning
• Integrated Gradient Correlation: a Dataset-wise Attribution Method
• Towards Visually Explaining Statistical Tests with Applications in Biomedical Imaging

Related papers

• A likelihood-based framework for simultaneously learning both noise and growth dynamics using biologically-informed neural networks
• Automated Lesion Segmentation of Stroke MRI Using nnU-Net: A Comprehensive External Validation Across Acute and Chronic Lesions
• Resolving satellite-in situ mismatches in Net Primary Production using high-frequency in situ bio-optical observations in the subpolar Northwest Atlantic
• easyplater: The easy way to generate microplate designs deconvolved from multivariate clinical data
• Essential Workers at Risk: An Agent-Based Model (SAFE-ABM) with Bayesian Uncertainty Quantification
• OmniBioTwin: A System-of-Twinned-Systems Framework for Health Digital Twins