SPINET: Sheaf Protein Inverse Folding Network

arXiv:2609.34153 · cs.LG, q-bio.BM · Submitted 2026-09-28 · Read on arXiv

cs.LG, q-bio.BM

Submitted: 2026-09-28

Updated: 2026-09-28

Code: https://github.com/UW-Madison-CBML/SPINET

Terminology

• Perplexity — 25× in this paper · explained in 3 episodes
• Ablation — 9× in this paper · explained in 1 episode
• Aggregation — 7× in this paper · explained in 1 episode
• Spectral Gap — 3× in this paper · explained in 5 episodes
• F1 Score — 2× in this paper · explained in 3 episodes
• Adam — 1× in this paper · explained in 2 episodes
• Bayesian Optimization — 1× in this paper · explained in 3 episodes
• Benchmark — 1× in this paper · explained in 2 episodes
• Clustering — 1× in this paper · explained in 2 episodes
• Distance Preservation — 1× in this paper · explained in 2 episodes
• Embeddings — 1× in this paper · explained in 2 episodes
• Fine-Tuning — 1× in this paper · explained in 5 episodes
• Flow Matching — 1× in this paper · explained in 8 episodes
• GNNs — 1× in this paper · explained in 2 episodes
• Interpretability — 1× in this paper · explained in 15 episodes

Sources

• All-atom inverse protein folding through discrete flow matching

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