Predicting Mutational Signature Exposures from H&E Whole Slide Images: A Pan-Cancer Feasibility Study

arXiv:2609.30985 · q-bio.QM · Submitted 2026-09-25 · Read on arXiv

q-bio.QM

Submitted: 2026-09-25

Updated: 2026-09-25

Code: https://github.com/flavio141/Hist2Sig-p

Terminology

• Cosine Similarity — 12× in this paper · explained in 3 episodes
• Calibration — 8× in this paper · explained in 7 episodes
• Domain Shift — 7× in this paper · explained in 4 episodes
• Embeddings — 5× in this paper · explained in 2 episodes
• Consistency — 4× in this paper · explained in 3 episodes
• Benchmark — 3× in this paper · explained in 2 episodes
• Foundation Model — 3× in this paper · explained in 3 episodes
• Cancer Genome Atlas — 2× in this paper
• Feature Extraction — 2× in this paper · explained in 2 episodes
• Foundation Models — 2× in this paper · explained in 7 episodes
• Hist2Sig and the Random Forest — 2× in this paper
• Multiple Instance Learning — 2× in this paper
• Transformer — 2× in this paper · explained in 2 episodes
• Zero-Inflated Negative Binomial — 2× in this paper
• Benchmarking — 1× in this paper · explained in 3 episodes
• Clinical Proteomic Tumor Analysis Consortium — 1× in this paper
• Composite Loss Function — 1× in this paper · explained in 2 episodes
• Core — 1× in this paper · explained in 2 episodes
• Decoupling — 1× in this paper · explained in 2 episodes
• External Validation — 1× in this paper · explained in 2 episodes
• Fine-Tuning — 1× in this paper · explained in 5 episodes
• Generalizability — 1× in this paper · explained in 6 episodes
• Generalization — 1× in this paper · explained in 13 episodes
• Loss Function — 1× in this paper · explained in 2 episodes
• Multiple Instance Learning (MIL) — 1× in this paper · explained in 2 episodes
• NCI Genomic Data Commons — 1× in this paper
• Objective Function — 1× in this paper · explained in 2 episodes
• Robustness — 1× in this paper · explained in 5 episodes
• Trace — 1× in this paper · explained in 2 episodes

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