Responsible Integration of AI in Cancer Genomics: Barriers, Risks, and Pathways to Trustworthy Clinical Translation

arXiv:2608.30912 · cs.AI, cs.CL · Submitted 2026-08-31 · Read on arXiv

cs.AI, cs.CL

Submitted: 2026-08-31

Updated: 2026-09-12

Terminology

• Explainability — 15× in this paper · explained in 3 episodes
• Provenance — 13× in this paper · explained in 4 episodes
• Foundation Model — 11× in this paper · explained in 3 episodes
• Foundation Models — 9× in this paper · explained in 7 episodes
• Interpretability — 9× in this paper · explained in 15 episodes
• Accountability — 7× in this paper · explained in 2 episodes
• Knowledge Graph — 7× in this paper · explained in 7 episodes
• European Health Data Space — 6× in this paper
• Verification — 5× in this paper · explained in 2 episodes
• Accuracy — 4× in this paper · explained in 1 episode
• Calibration — 4× in this paper · explained in 7 episodes
• Graph Construction — 4× in this paper · explained in 3 episodes
• Aggregation — 3× in this paper · explained in 1 episode
• Benchmark — 3× in this paper · explained in 2 episodes
• Benchmarking — 3× in this paper · explained in 3 episodes
• Cancer Genome Atlas — 3× in this paper
• Core — 3× in this paper · explained in 2 episodes
• Data Sovereignty — 3× in this paper · explained in 2 episodes
• European Interoperability Framework — 3× in this paper
• External Validation — 3× in this paper · explained in 2 episodes
• Medical Device Regulation — 3× in this paper
• Uncertainty Quantification — 3× in this paper · explained in 8 episodes
• Artificial Intelligence (AI) — 2× in this paper · explained in 2 episodes
• Cancer Research Data Commons — 2× in this paper
• Consistency — 2× in this paper · explained in 3 episodes
• Decision-Support Tool — 2× in this paper · explained in 2 episodes
• Federated Learning — 2× in this paper · explained in 14 episodes
• In Vitro Diagnostic Medical Devices Regulation — 2× in this paper
• International Cancer Genome Consortium — 2× in this paper
• Multimodal Integration — 2× in this paper · explained in 2 episodes
• Robustness — 2× in this paper · explained in 5 episodes
• Transformer — 2× in this paper · explained in 2 episodes
• AI Integration — 1× in this paper · explained in 1 episode
• Abstention — 1× in this paper · explained in 1 episode
• Actionability — 1× in this paper · explained in 3 episodes
• Adam — 1× in this paper · explained in 2 episodes
• Alignment — 1× in this paper · explained in 1 episode
• Annotator Agreement — 1× in this paper · explained in 1 episode
• Causal Reasoning — 1× in this paper · explained in 2 episodes
• Computational Biology — 1× in this paper · explained in 2 episodes
• Differential Privacy — 1× in this paper · explained in 4 episodes
• EU General Data Protection Regulation — 1× in this paper
• Elias — 1× in this paper · explained in 2 episodes
• Embeddings — 1× in this paper · explained in 2 episodes
• Fidelity — 1× in this paper · explained in 2 episodes
• Generalizability — 1× in this paper · explained in 6 episodes
• Human-in-the-Loop — 1× in this paper · explained in 3 episodes
• Knowledge graphs — 1× in this paper · explained in 2 episodes
• Large Language Models (LLMs) — 1× in this paper · explained in 6 episodes
• Multimodal Learning — 1× in this paper · explained in 2 episodes
• Trace — 1× in this paper · explained in 2 episodes

Sources

• The Disagreement Problem in Explainable Machine Learning: A Practitioner's Perspective

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