An extreme ram-pressure stripping event in a protocluster at redshift 4.3

In the nearby Universe, the environment plays a crucial role in suppressing star formation in dense regions. In particular, ram-pressure stripping (RPS) is a major mechanism for removing gas from galaxies in clusters, occurring when galaxies travel through a dense hot atmosphere and leave trailing gaseous wakes. By depleting the cold gas reservoir, RPS can drive outside-in quenching and is therefore thought to be an important route for transforming cluster galaxies. At earlier times, however, the hot atmosphere in protoclusters is expected to be immature, so environmental effects are commonly assumed to be dominated by gravitational interactions. Here we report ALMA and JWST observations of SPT2349 - 56-C26 (hereafter C26), a massive galaxy experiencing an extreme RPS event in the SPT2349 - 56 protocluster at z, =,4.3. More than half of the [CII]-traced cold gas lies outside its stellar body, with the emission peak offset by 6 kpc. These observations show that RPS can remove most of the cold gas from massive galaxies in dense protocluster cores as early as z, =,4.3, providing a direct hydrodynamic pathway for environmental quenching at z, >,4.